Van de Ven Brace Halts Everton's Run at New Stadium
The Dutch defender became the initial backline player to score two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven nods home twice in first half
Everton's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr nets final goal in dying moments
This loss is Everton's first at their new ground
Micky van de Ven found the net twice as Spurs prolonged their unbeaten run on the road in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their five previous fixtures at their new ground at the dockside location, having departed their historic home behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman pounced twice from set-pieces in the opening 45 minutes to put their strong form at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - nodded in a final goal to put the game to bed.
The Everton defender thought he had levelled the scores a short while after the defender's first goal, glancing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a number of chances, while Vicario made a succession of excellent stops to guarantee Tottenham went five away games unbeaten in the English top flight.
But the video assistant referee intervened, advising the match official to review the goal on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves Thomas Frank's team into third place in the Premier League, five points off north London rivals and leaders Arsenal.
The Merseyside club remain 14th and sit half a dozen points ahead of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of the field
Following a drab midweek performance in the European competition against the French side, where they managed a mere two shots on target, the manager chose the French striker in attack instead of former Toffees player the Brazilian.
The summer signing was failed to make much of an impact before being substituted for Richarlison after 60 minutes on the field, but it emerged he wasn't needed in the final outcome.
Defender the Dutchman converted into an offensive threat to be reckoned with.
Spurs' first goal came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball toward the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's unavailability - added his second in first-half stoppage time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as outstanding in defence, combining well with his defensive colleague as the duo dealt excellently with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a happy hunting ground, but it seems the freshness may have worn off slightly and supporters flocked to the gates after Sarr's third for Tottenham.
The end in Everton's unbeaten home run won't be a massive concern for David Moyes, but their striker situation are.
Beto and the other striker - the Everton's two recognised centre-forwards - had scored just one league goal combined before the weekend's match.
And they were failed to contribute to that miserable record on a wet and gloomy evening on in Liverpool.
The striker's form was summed up when he chose to overhead kick a clear chance from close range, despite having room and time to reposition for a more conventional shot that would have challenged Vicario.
Barry, too, was unable to make an impact after replacing Beto in the second half.
It was not for a lack of opportunity. Most of Everton's offensive moves came through the winger and the forward, who tirelessly whipped threatening balls into the Tottenham penalty area.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the top flight on early November at 8 PM.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.